{"id":26062,"date":"2022-02-21T18:28:53","date_gmt":"2022-02-21T10:28:53","guid":{"rendered":"https:\/\/www.accscicn.com\/?p=26062"},"modified":"2022-10-20T17:50:20","modified_gmt":"2022-10-20T09:50:20","slug":"app-mantis-2022022104","status":"publish","type":"post","link":"https:\/\/www.accscicn.com\/es\/vision\/aplicacion\/aplicacion-mantis-2022022104\/","title":{"rendered":"Expansi\u00f3n del cultivo de organoides con el procesador de l\u00edquidos MANTIS\u00ae: un estudio de caso del MIT"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"26062\" class=\"elementor elementor-26062\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7c68707e elementor-section-full_width elementor-section-stretched elementor-section-height-default elementor-section-height-default\" data-id=\"7c68707e\" data-element_type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3a64237d\" data-id=\"3a64237d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-41941a0 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"41941a0\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-1ddc8218\" data-id=\"1ddc8218\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2b3608e3 elementor-widget elementor-widget-heading\" data-id=\"2b3608e3\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.21.0 - 20-05-2024 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h3 class=\"elementor-heading-title elementor-size-default\">Expansi\u00f3n del cultivo de organoides con el procesador de l\u00edquidos MANTIS\u00ae: un estudio de caso del MIT<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-730a2efc elementor-widget elementor-widget-text-editor\" data-id=\"730a2efc\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.21.0 - 20-05-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p>Los organoides permiten a los investigadores estudiar la biolog\u00eda de los tejidos con una fidelidad extraordinaria. Mediante el uso de sistemas de cultivo in vitro en 3D para mostrar caracter\u00edsticas clave de \u00f3rganos espec\u00edficos, estas complejas estructuras multicelulares nos han proporcionado conocimientos fisiol\u00f3gicamente relevantes que han ayudado a avanzar en muchas \u00e1reas de investigaci\u00f3n. Una de las principales limitaciones del cultivo tradicional de organoides es que suele ser un proceso muy laborioso que requiere personal altamente especializado para lograr un rendimiento medio. Gracias al procesador de l\u00edquidos MANTIS\u00ae de FORMULATRIX, los investigadores del laboratorio Shalek del Instituto Tecnol\u00f3gico de Massachusetts (MIT) pudieron analizar r\u00e1pidamente m\u00e1s de 450 dosis diferentes de peque\u00f1as mol\u00e9culas para determinar su capacidad de potenciar la diferenciaci\u00f3n de las c\u00e9lulas de Pann en organoides del intestino delgado. El MANTIS\u00ae proporciona un nivel de rendimiento previamente inalcanzable y es esencial para avanzar en la comprensi\u00f3n de m\u00faltiples cambios en un material de muestra limitado.<\/p><p><strong>La barrera epitelial intestinal es una importante diana terap\u00e9utica<\/strong><\/p><p>Las barreras tisulares formadas por c\u00e9lulas de la piel, las v\u00edas respiratorias y los intestinos proporcionan interacci\u00f3n con el entorno y protecci\u00f3n frente a \u00e9l. Equilibran los niveles de fluidos, nutrientes, electrolitos y residuos metab\u00f3licos, colaboran estrechamente con el sistema inmunitario en la defensa frente a agentes pat\u00f3genos y desempe\u00f1an un papel importante en la vigilancia y erradicaci\u00f3n de tumores.<\/p><p>La disfunci\u00f3n de la barrera tisular est\u00e1 asociada a una amplia gama de estados patol\u00f3gicos, como infecciones, c\u00e1ncer, alergias y diversas enfermedades autoinmunes. Aunque las exposiciones ambientales pueden mitigarse con terapias como antivirales y antibi\u00f3ticos, y las respuestas inmunitarias pueden modificarse con vacunas e inmunoterapia, en algunos casos el problema no puede resolverse con los m\u00e9todos existentes.<\/p><p><img fetchpriority=\"high\" decoding=\"async\" class=\"size-large wp-image-26065 alignnone\" src=\"https:\/\/www.accscicn.com\/wp-content\/uploads\/2022\/02\/10-1024x905.png\" alt=\"\" width=\"1024\" height=\"905\" srcset=\"https:\/\/www.accscicn.com\/wp-content\/uploads\/2022\/02\/10-1024x905.png 1024w, https:\/\/www.accscicn.com\/wp-content\/uploads\/2022\/02\/10-300x265.png 300w, https:\/\/www.accscicn.com\/wp-content\/uploads\/2022\/02\/10-768x679.png 768w, https:\/\/www.accscicn.com\/wp-content\/uploads\/2022\/02\/10.png 1254w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/p><p>Pese a ser un componente clave de la barrera tisular, la barrera epitelial intestinal se ha infrautilizado hasta ahora como diana terap\u00e9utica. Mediante el uso de sistemas organoides para modelizar distintas fuentes de tejido de barrera epitelial intestinal, los investigadores pueden comprender mejor estos complejos sistemas y desarrollar as\u00ed terapias para tratar una amplia gama de enfermedades.<\/p><p>\u00a0<\/p><p><strong>Los modelos org\u00e1nicos impulsan la investigaci\u00f3n<\/strong><\/p><p>Los organoides representan uno de los avances m\u00e1s valiosos de los \u00faltimos a\u00f1os en la investigaci\u00f3n con c\u00e9lulas madre. Derivados de c\u00e9lulas madre adultas individuales, muestras de tejidos que contienen c\u00e9lulas madre adultas o mediante diferenciaci\u00f3n dirigida de c\u00e9lulas madre pluripotentes, los organoides contienen poblaciones de c\u00e9lulas madre capaces de diferenciarse en tipos celulares espec\u00edficos de \u00f3rganos. Estas c\u00e9lulas presentan una organizaci\u00f3n espacial y una funci\u00f3n similares a las del \u00f3rgano que representan, dando lugar a sistemas fisiol\u00f3gicamente relevantes que imitan las condiciones in vivo.<\/p><p><img decoding=\"async\" class=\"size-large wp-image-26066 alignnone\" src=\"https:\/\/www.accscicn.com\/wp-content\/uploads\/2022\/02\/11-1024x763.png\" alt=\"\" width=\"1024\" height=\"763\" srcset=\"https:\/\/www.accscicn.com\/wp-content\/uploads\/2022\/02\/11-1024x763.png 1024w, https:\/\/www.accscicn.com\/wp-content\/uploads\/2022\/02\/11-300x224.png 300w, https:\/\/www.accscicn.com\/wp-content\/uploads\/2022\/02\/11-768x572.png 768w, https:\/\/www.accscicn.com\/wp-content\/uploads\/2022\/02\/11.png 1060w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/p><p><em>Fig. 1. Los \u00f3rganos an\u00e1logos presentan una organizaci\u00f3n espacial y una funci\u00f3n similares a las de los \u00f3rganos representativos, como la morfolog\u00eda cripta\/vellosidad de este an\u00e1logo del intestino delgado.<\/em><\/p><p>\u00a0<\/p><p><strong>Estudios sobre organoides limitados por el flujo<\/strong><\/p><p>Existen varias formas de cultivar organoides. Entre ellas se incluye el cultivo de c\u00e9lulas madre en presencia de una capa alimentadora de fibroblastos o en la superficie de una matriz biomaterial controlada, pero el m\u00e9todo m\u00e1s popular consiste en encapsular c\u00e9lulas madre en una matriz extracelular (MEC) de origen biol\u00f3gico, como Matrigel\u00ae. Al encapsular una c\u00fapula de Matrigel\u00ae inoculada en una placa con un medio de cultivo celular que contiene factores de crecimiento espec\u00edficos, las c\u00e9lulas proliferan posteriormente para formar una estructura tridimensional que representa el \u00f3rgano de inter\u00e9s para el investigador.<\/p><p><img decoding=\"async\" class=\"size-large wp-image-26067 alignnone\" src=\"https:\/\/www.accscicn.com\/wp-content\/uploads\/2022\/02\/12-1024x764.png\" alt=\"\" width=\"1024\" height=\"764\" srcset=\"https:\/\/www.accscicn.com\/wp-content\/uploads\/2022\/02\/12-1024x764.png 1024w, https:\/\/www.accscicn.com\/wp-content\/uploads\/2022\/02\/12-300x224.png 300w, https:\/\/www.accscicn.com\/wp-content\/uploads\/2022\/02\/12-768x573.png 768w, https:\/\/www.accscicn.com\/wp-content\/uploads\/2022\/02\/12.png 1054w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/p><p><em>Figura 2. La c\u00fapula de Matrigel\u00ae encapsula las c\u00e9lulas madre y promueve su proliferaci\u00f3n para formar estructuras tridimensionales fisiol\u00f3gicamente relevantes.<\/em><\/p><p>La inoculaci\u00f3n de placas de organoides en la c\u00fapula de Matrigel\u00ae tiene tres requisitos espec\u00edficos: 1) deposici\u00f3n precisa de ECM que contenga c\u00e9lulas en placas de cultivo de tejidos precalentadas, evitando los bordes de los pocillos para mantener la forma de c\u00fapula necesaria para un crecimiento m\u00e1ximo; 2) manipulaci\u00f3n precisa en vol\u00famenes muy peque\u00f1os, ya que el material de muestra suele ser muy limitado; y 3) un grado razonable de control de la temperatura, ya que Matrigel\u00ae y sustratos similares existen como l\u00edquidos viscosos a 4 \u00b0C y requieren una superficie y un entorno c\u00e1lidos para formar hidrogeles curados.<\/p><p>Debido a estos requisitos, la miniaturizaci\u00f3n de los cultivos de organoides a una escala compatible con los equipos de cribado convencionales (formatos de 96\/384\/1536 pocillos) es extremadamente dif\u00edcil. Aunque el proceso de deposici\u00f3n de Matrigel\u00ae, bastante trivial y lento, puede realizarse manualmente en placas de 48 pocillos, las tasas de formaci\u00f3n de gotas err\u00f3neas aumentan significativamente en vol\u00famenes de placa de pocillos mayores y limitan enormemente la reproducibilidad de los experimentos.<\/p><p>\u00a0<\/p><p><strong>MANTIS\u00ae es una soluci\u00f3n de sobremesa para la investigaci\u00f3n de organoides miniaturizados<\/strong><\/p><p>Para superar las limitaciones de los m\u00e9todos manuales de deposici\u00f3n de Matrigel\u00ae, los investigadores del laboratorio Shalek del MIT utilizaron el procesador de l\u00edquidos MANTIS\u00ae de FORMULATRIX para dispensar gotas de Matrigel\u00ae en diversos formatos de placa (hasta 384 pocillos). El objetivo de este estudio era completar una campa\u00f1a de cribado de compuestos utilizando el sistema de organoides del intestino delgado a una escala adecuada para los m\u00e9todos de alto rendimiento.<\/p><p>MANTIS\u00ae utiliza un dispensador microflu\u00eddico sin contacto de un solo canal para suministrar reactivos individuales a un \u00fanico pocillo cada vez, confinando el l\u00edquido a chips desechables para evitar la contaminaci\u00f3n cruzada y eliminando la necesidad de limpieza. El CV de menos de 31 TP3T, l\u00edder del sector, permite suministrar vol\u00famenes precisos de hasta 0,1 \u00b5l, al tiempo que ofrece flexibilidad para m\u00faltiples flujos de trabajo, ya que admite de 6 a 48 chips y maneja soluciones acuosas de hasta 25 cP (equivalentes a aproximadamente 601 TP3T de glicerol a temperatura ambiente).<\/p><p>Adem\u00e1s de estas caracter\u00edsticas, MANTIS ocupa s\u00f3lo 1 pie3, por lo que puede instalarse f\u00e1cilmente en entornos con temperatura controlada, como frigor\u00edficos o incubadoras. Tambi\u00e9n es compatible con una amplia gama de software e instrumentos de laboratorio y puede integrarse perfectamente en los flujos de trabajo existentes.<\/p><p><img loading=\"lazy\" decoding=\"async\" class=\"size-large wp-image-26068 alignnone\" src=\"https:\/\/www.accscicn.com\/wp-content\/uploads\/2022\/02\/13-1024x532.png\" alt=\"\" width=\"1024\" height=\"532\" srcset=\"https:\/\/www.accscicn.com\/wp-content\/uploads\/2022\/02\/13-1024x532.png 1024w, https:\/\/www.accscicn.com\/wp-content\/uploads\/2022\/02\/13-300x156.png 300w, https:\/\/www.accscicn.com\/wp-content\/uploads\/2022\/02\/13-768x399.png 768w, https:\/\/www.accscicn.com\/wp-content\/uploads\/2022\/02\/13.png 1448w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/p><p><em>Figura 3. El MANTIS\u00ae ocupa muy poco espacio y puede sellarse en un entorno de temperatura controlada. La colocaci\u00f3n de MANTIS\u00ae en un frigor\u00edfico en este experimento permiti\u00f3 la inoculaci\u00f3n de placas de Matrigel\u00ae en una superficie calentada a 4\u00b0C (gris = fr\u00edo, rojo = caliente). Estas son las condiciones ideales para la formaci\u00f3n de una c\u00fapula de Matrigel\u00ae.<\/em><\/p><p><strong>La miniaturizaci\u00f3n de los cultivos de organoides del intestino delgado proporciona informaci\u00f3n clave<\/strong><\/p><p>Ben Mead, becario posdoctoral del laboratorio de Shalek en el MIT, y sus colegas utilizaron MANTIS\u00ae para miniaturizar un flujo de trabajo existente y cribar una biblioteca de compuestos en el sistema de organoides del intestino delgado con el fin de identificar mol\u00e9culas herramienta que puedan potenciar la diferenciaci\u00f3n de las c\u00e9lulas de Pan. \u00c9stas son las principales c\u00e9lulas productoras de antimicrobianos del intestino delgado humano y son esenciales para la funci\u00f3n de barrera epitelial.<\/p><p>Tras la aplicaci\u00f3n de medidas estad\u00edsticas s\u00f3lidas (a\u00fan no publicadas), Mead y sus colegas han identificado una serie de compuestos semilleros. Algunos de ellos han pasado a estudios de seguimiento, lo que supone una importante oportunidad para perfilar nuevas dianas biol\u00f3gicas a tener en cuenta para la diferenciaci\u00f3n dirigida de las c\u00e9lulas de Pan.<\/p><p><strong>La ampliaci\u00f3n aumenta las oportunidades de la medicina personalizada<\/strong><\/p><p>Varias caracter\u00edsticas clave del MANTIS\u00ae respaldan los hallazgos de los investigadores del MIT. Al dispensar gotas de Matrigel\u00ae mediante un \u00fanico brazo libre, el MANTIS\u00ae puede proporcionar una inoculaci\u00f3n precisa de placas en diversos formatos (hasta 384 pocillos) para aumentar la escala de los experimentos. El instrumento tambi\u00e9n puede alojar placas de 1536 pocillos, lo que permite ampliar el rendimiento seg\u00fan sea necesario.<\/p><p>Las puntas de pipeta lavables y desechables conectadas al chip permiten a los investigadores del MIT manejar vol\u00famenes de muestra limitados, al tiempo que reducen las necesidades de reactivos y los costes asociados. Adem\u00e1s, el reducido tama\u00f1o del MANTIS\u00ae permite instalar f\u00e1cilmente todo el dispositivo en un frigor\u00edfico est\u00e1ndar y combinarlo con un bloque de precalentamiento para depositar con precisi\u00f3n gotas de Matrigel\u00ae enfriadas sobre la superficie de cultivo tisular precalentada (v\u00e9ase la figura 4); esta inoculaci\u00f3n en placa supone una mejora significativa con respecto a la t\u00e9cnica manual.<\/p><p><img loading=\"lazy\" decoding=\"async\" class=\"size-large wp-image-26069 alignnone\" src=\"https:\/\/www.accscicn.com\/wp-content\/uploads\/2022\/02\/14-1024x301.png\" alt=\"\" width=\"1024\" height=\"301\" srcset=\"https:\/\/www.accscicn.com\/wp-content\/uploads\/2022\/02\/14-1024x301.png 1024w, https:\/\/www.accscicn.com\/wp-content\/uploads\/2022\/02\/14-300x88.png 300w, https:\/\/www.accscicn.com\/wp-content\/uploads\/2022\/02\/14-768x226.png 768w, https:\/\/www.accscicn.com\/wp-content\/uploads\/2022\/02\/14-1536x452.png 1536w, https:\/\/www.accscicn.com\/wp-content\/uploads\/2022\/02\/14.png 1794w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/p><p><em>Figura 4. MANTIS\u00ae reduce significativamente los requisitos de reactivos, incluido el volumen de Matrigel\u00ae por pocillo, el volumen de medio de inoculaci\u00f3n de la placa y el n\u00famero de organoides intestinales inoculados, al tiempo que reduce el tiempo de inoculaci\u00f3n de la placa.<\/em><\/p><p>Investigadores del MIT han demostrado que el enfoque miniaturizado que ofrece MANTIS\u00ae es eficaz para estudiar m\u00faltiples variaciones de materiales limitados. Esto es relevante para la detecci\u00f3n de organoides a partir de biopsias de pacientes individuales y abre muchas nuevas oportunidades para la medicina personalizada. La inclusi\u00f3n de modalidades de medici\u00f3n adicionales mejorar\u00e1 a\u00fan m\u00e1s la fidelidad del modelo a medida que evolucione la tecnolog\u00eda, y MANTIS\u00ae es clave para hacer realidad la necesidad de una mayor escala.<\/p><p>\u00a0<\/p><p>Fuente: @BostonFummerle<\/p><p>Fecha: 2022.01.11<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-11f23c3d\" data-id=\"11f23c3d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1929b12c elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"1929b12c\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.21.0 - 20-05-2024 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class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Productos relacionados<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2f066642 elementor-grid-1 elementor-grid-tablet-2 elementor-grid-mobile-1 elementor-posts--thumbnail-top elementor-widget elementor-widget-posts\" data-id=\"2f066642\" data-element_type=\"widget\" data-settings=\"{&quot;classic_columns&quot;:&quot;1&quot;,&quot;classic_columns_tablet&quot;:&quot;2&quot;,&quot;classic_columns_mobile&quot;:&quot;1&quot;,&quot;classic_row_gap&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:35,&quot;sizes&quot;:[]},&quot;classic_row_gap_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;classic_row_gap_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"posts.classic\">\n\t\t\t\t<div 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href=\"https:\/\/www.accscicn.com\/es\/producto\/manipulador-de-liquidos-tempest\/\" aria-label=\"M\u00e1s informaci\u00f3n sobre Formulatrix Tempest\u5206\u6db2\u4eea\" tabindex=\"-1\" >\n\t\t\tLeer M\u00e1s \"\t\t<\/a>\n\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-25594 page type-page status-publish hentry category-product category-biological-drugs tag-formulatrix-mantis tag-formulatrix\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h3 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/www.accscicn.com\/es\/producto\/manipulador-de-liquidos-mantis\/\" >\n\t\t\t\tDispensador de microplacas Formulatrix Mantis\t\t\t<\/a>\n\t\t<\/h3>\n\t\t\t\t<div class=\"elementor-post__excerpt\">\n\t\t\t<p>\u7f8e\u56fdFormulatrix\u7eb3\u5347\u7ea7\u5fae\u91cf\u81ea\u52a8<\/p>\n\t\t<\/div>\n\t\t\n\t\t<a class=\"elementor-post__read-more\" href=\"https:\/\/www.accscicn.com\/es\/producto\/manipulador-de-liquidos-mantis\/\" 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[&hellip;]<\/p>","protected":false},"author":1,"featured_media":26066,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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